Clinical value of C-reactive protein and procalcitonin in the diagnosis of Uyghur bacteria-negative pulmonary tuberculosis
C反应蛋白和降钙素原在维吾尔族菌阴肺结核诊断中的临床价值

摘要

目的 探讨C反应蛋白和降钙素原在维吾尔族菌阴肺结核诊断中的临床价值，以及在社区获得性肺炎临床鉴别中的意义。方法 在维吾尔族病例中分别检测200例菌阴肺结核、200例社区获得性肺炎和100名健康体检者的PCT、CRP、红细胞沉降率（ESR）、白细胞计数（WBC）、中性粒细胞百分比（NEUT%）及胸部CT。比较三组研究对象C反应蛋白（CRP）、降钙素原（PCT）、白细胞计数（WBC）、中性粒细胞计数百分比（NEUT%）检测水平, 并比较A组与B组PCT、CRP诊断阳性率的差异。结果 三组研究对象CRP、PCT、WBC、NEUT%检测水平比较，差异具有统计学意义（P<0.05），进一步组间比较，结核组、肺炎组患者CRP、PCT、WBC、NEUT%检测水平均明显高于对照组，且结核组CRP、PCT、WBC、NEUT%检测水平又明显低于肺炎组，差异均具有统计学意义（P<0.05）。以病理学结果为金标准，分析CRP、PCT、WBC、NEUT%单一及联合诊断细菌感染效能，结果显示，与单独检测比较，CRP、PCT、WBC、NEUT%联合检测敏感度、特异度均明显更高。结论 C反应蛋白和降钙素原在维吾尔族菌阴肺结核中较社区获得性肺炎患者水平低，且联合检测诊断价值更高，有利于指导治疗方案的制定，进一步有效改善患者预后。

Abstract

Objective To investigate the clinical value of C-reactive protein and procalcitonin in the diagnosis of Uyghur bacteria-negative pulmonary tuberculosis, and their significance in the clinical identification of community-acquired pneumonia.
Methods PCT, CRP, erythrocyte sedimentation rate (ESR), white blood cell count (WBC), neutrophil percentage (NEUT%) and chest CT. The detection levels of C-reactive protein (CRP), procalcitonin (PCT), white blood cell count (WBC), and neutrophil count percentage (NEUT%) were compared among the three groups, and the diagnosis of PCT and CRP in group A and group B were compared. difference in positive rates.
Results There were statistically significant differences in the detection levels of CRP, PCT, WBC, and NEUT% among the three groups of subjects (P<0.05). For further comparison between groups, the detection levels of CRP, PCT, WBC, and NEUT% in the tuberculosis group and the pneumonia group were all the same. Significantly higher than the control group, and the detection levels of CRP, PCT, WBC, and NEUT% in the tuber- culosis group were significantly lower than those in the pneumonia group, with statistical significance (P<0.05). Taking the pathological results as the gold standard, the single and combined diagnostic efficacy of CRP, PCT, WBC, NEUT% in diagnosing bacterial infection was analyzed. higher.
Conclusion   The levels of C-reactive protein and procalcitonin in Uyghur bacteria-negative pulmonary tuberculosis are lower than those in patients with community-acquired pneumonia, and the combined detection has higher diagnostic value, which is beneficial to guide the formulation of treatment plans and further effectively improve the prognosis of patients.