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Open Access Article

Journal of Modern Life Sciences Research. 2023; 4: (1) ; 5-8 ; DOI: 10.12208/j.jlsr.20230002.

The reseach progress of CircRNA regulatinglipid metabolic pathways to affect the hepatocellular carcinoma
CircRNA调控脂代谢通路来影响肝癌的研究进展

作者: 樊榕, 牛紫仪, 嵇福森, 闫涛, 崔静怡, 李钠 *

上海健康医学院医学技术学院 上海

*通讯作者: 李钠,单位:上海健康医学院医学技术学院 上海;

发布时间: 2023-03-14 总浏览量: 976

摘要

中国是全球肝细胞癌(hepatocellular carcinoma, HCC)发病率最高的地区之一,其发病率与病死率均位居世界首位。影响肝癌的因素众多,其中脂代谢异常与肝癌的发展密切相关。许多研究证明CircRNA能够通过影响脂代谢通路关键酶、脂滴形成等进而影响肝癌的进展。本文就相关的最新研究进行综述,旨在开发以CircRNA 等为代表的早期有效标志物,为肝癌的早发现、早治疗提供依据。

关键词: 肝癌;脂代谢通路;CircRNA;标志物

Abstract

China is one of the areas with the highest incidence of hepatocellular carcinoma (HCC) in the world, and its incidence and mortality rates rank first in the world. There are many factors affecting hepatocellular carcinoma, among which abnormal lipid metabolism is closely related to the its development. Many evidence have proved that circRNA can affect the progression of liver cancer by affecting key enzymes in the lipid metabolism pathway, lipid droplet formation and et.al. This article reviews the latest related research, aiming to develop early effective markers represented by circRNA, to provide a basis for early detection and early treatment of liver cancer.

Key words: hepatocellular carcinoma; lipid metabolism; CircRNA; biomarker

参考文献 References

[1] Sun, H., Y. Song and X. Wang, Effects of Different Anesthetic Methods on Cellular Immune and Neuroendocrine Functions in Patients With Hepatocellular Carcinoma Before and After Surgery. Journal of clinical laboratory analysis, 2016. 30(6).

[2] Beloribi-Djefaflia, S., S. Vasseur and F. Guillaumond, Lipid metabolic reprogramming in cancer cells. Oncogene-sis, 2016. 5(1).

[3] 陈诗芮等, CircRNA调控脂质代谢对相关疾病进展的影响. 生命的化学, 2022. 42(09): 第1685-1693页.

[4] 王玉敏等, MicroRNAs靶向脂代谢重编程参与肝细胞癌发生的研究进展. 基础医学与临床, 2022. 42(12): 第1930-1934页.

[5] Peck, B. and A. Schulze, Lipid desaturation - the next step in targeting lipogenesis in cancer? The FEBS journal, 2016. 283(15).

[6] Zuzanna, T. and D. Pawel, Stearoyl-CoA Desaturase 1 as a Therapeutic Target for the Treatment of Cancer. Cancers, 2019. 11(7).

[7] Li, Q., et al., circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells. Cell Reports, 2022. 41(8).

[8] Yan, S., et al., Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases: an update. World journal of gastroenterology, 2015. 21(12).

[9] Guo, X., et al., Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis. BioMed research international, 2017. 2017.

[10] Yang, W., et al., Hsa_circ_0048179 attenuates free fatty acid-induced steatosis via hsa_circ_0048179/miR-188-3p/GPX4 signaling. Aging, 2020. 12(23).

[11] Li, J., et al., A nanodrug system overexpressed circRNA

_0001805 alleviates nonalcoholic fatty liver disease via miR-106a-5p/miR-320a and ABCA1/CPT1 axis. Journal of Nanobiotechnology, 2021. 19(1).

[12] Xing-Ya, G., et al., circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling. World Journal of Gastroenterology, 2018. 24(03): p. 323-337.

[13] Xing-Ya, G., et al., circRNA_0046367 Prevents Hepatoxi-city of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis. Oxidative Medicine and Cellular Longevity, 2017. 2017.

[14] Stefano, V., Intracellular Lipid Droplets: From Structure to Function. Lipid Insights, 2017. 10.

[15] Shiro, K. and M. Yohei, Lipid Droplets: A Key Cellular Organelle Associated with Cancer Cell Survival under Normoxia and Hypoxia. IJMS, 2016. 17(9).

[16] Jeremy, E.W. and A.S. Phillip, A Circuitous Route to Noncoding RNA. Science, 2013. 340(6131).

[17] Jin, X., et al., Antagonizing circRNA_002581-miR-122-CPEB1 axis alleviates NASH through restoring PTEN-AMPK-mTOR pathway regulated autophagy. Cell death & disease, 2020. 11(2).

[18] Chen, X., et al., Circ_0057558 promotes nonalcoholic fatty liver disease by regulating ROCK1/AMPK signaling through targeting miR-206. Cell Death & Disease, 2021. 12(9).

[19] Li, P., et al., CircScd1 Promotes Fatty Liver Disease via the Janus Kinase 2/Signal Transducer and Activator of Transcription 5 Pathway. Digestive diseases and sciences, 2019. 64(1).

[20] Li, J., et al., A nanodrug system overexpressed circRNA_0001805 alleviates nonalcoholic fatty liver disease via miR-106a-5p/miR-320a and ABCA1/CPT1 axis. Journal of Nanobiotechnology, 2021. 19(1).

引用本文

樊榕, 牛紫仪, 嵇福森, 闫涛, 崔静怡, 李钠, CircRNA调控脂代谢通路来影响肝癌的研究进展[J]. 现代生命科学研究, 2023; 4: (1) : 5-8.